MTHFR C677T Mutation - What Does That Actually Mean?

What Are The Health Risks of C677T Mutation?

According to SNPedia, which compiles research on genetics, C677T mutants have been shown in at least one research study to have an increased risk for:

• Cardiac-related issues including:

  • Thrombosis (increased tendency to clot inappropriately)

  • High homocysteine levels (a heart risk)

  • Pre-eclampsia (dangerous high blood pressure in pregnancy)

  • Vascular dementia

• Fertility issues including:

  • Multiple pregnancy loss

  • Low sperm count

  • Birth defects such as down syndrome

• Neurological issues including:

  • Migraines

  • Autism

  • Alzheimer’s dementia

• Mood and psychological issues including:

  • Depression

  • Anxiety

  • Schizophrenia

Here are the common recommendations for supporting those with C677T MTHFR mutations:

1. Limit ingestion of folic acid in fortified foods as you cannot process folic acid well.

2. Limit or cease taking supplements or drugs with folic acid in them. Talk with your doctor before stopping.

3. Avoid folic acid blocking drugs such as birth control or Methotrexate.

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