Cancer Risk in Women Using the Levonorgestrel-Releasing Intrauterine System in Finland

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Soini, Tuuli MD; Hurskainen, Ritva MD; Grénman, Seija MD; Mäenpää, Johanna MD; Paavonen, Jorma MD; Pukkala, Eero Phd

Obstetrics & Gynecology 124(2 PART 1):p 292-299, August 2014.

“OBJECTIVE: 

To examine the association between premenopausal use of the levonorgestrel-releasing intrauterine system and cancer incidence in Finland with a special focus on endometrial adenocarcinoma.”

“CONCLUSION: 

The levonorgestrel-releasing intrauterine system may have a protective effect against endometrial malignant transformation. Using the levonorgestrel-releasing intrauterine system for treatment of menorrhagia during reproductive years was associated with a lower incidence of endometrial, ovarian, pancreatic, and lung cancers than expected. Levonorgestrel-releasing intrauterine system use was associated with a higher than expected incidence of breast cancer.”