Chronic Systemic Toxicity Study of Copper Intrauterine Devices in Female Wistar Rats

Chronic Systemic Toxicity Study of Copper Intrauterine Devices in Female Wistar Rats

The aim of this study was to evaluate the chronic systemic and local toxicity of a copper intrauterine device in a rat model. These results obtained at different dosages and long-term implantation provide solid data confirming the safety of long-term use of Cu-IUDs. However, the elevated leucocyte levels found in this study warrant further investigation.

Includes lots of references to other studies.

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Copper-7 intrauterine device (Gravigard). Report of experience.

Copper-7 intrauterine device (Gravigard). Report of experience.

“Compared with oral contraceptives copper IUDs have less severe side effects but less safety at the same time-especially for the younger fertile age group. Therefore they should be offered to young nulliparous women only for a limited period of time.”

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